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Kratom In Bulk Richards

There are many more drugs derived from plants which are successfully established as pharmaceuticals which I have not covered in this section. Kratom In Bulk Richards scientific research in phytopharmaceutical is on going and

is growing rapidly especially in

<img Kratom In Bulk Richards src=’http://migraineremedy.info/images/Best_Migraine_Pain_Medication_59dd.jpg’ kratom legal poland alt=’Kratom In Bulk Richards’>

countries like Malaysia which have an abundance of natural resources. In spite of much activity on the chemistry and pharmacology of phytopharmaceuticals thorough investigations on their potential toxicology are lacking. Drew and Myers 1997).

Illustration of two main pathways of apoptosis extrinsic (death receptor) and intrinsic (mitochondria) Kratom In Bulk Richards pathways with the final execution via caspases 3 6 and 7. This diagram was taken from Igney and Krammer (2002). Diagram showing the cross-talk of organelles during cell death. Cells can execute cell death via apoptosis or caspase- independent pathway (necrosislike PCD or apoptosis-like PCD).

Many commercial kits tailored to detect several important caspases such as Caspase 3 7 8 and 9 are readilyavailable and most of them can either be analysed via flow cytometry fluorescence or even absorbance measurement. The assessment of p53 levels and its target gene p21 which are highly associated with apoptotic cell death can also be investigated using many in vitro approach such as immunoblotting (Western blot) fluorescence image cytometry etc (Mckenzie et al 1999). The generation of ROS in mediating the cell death should also be a major concern in investigating the in vitro assessment of cel death as ROS is a major indicator for mitochondrial kratom first experience dysfunction which in turn could activate many forms of programmed cell death (Tan et al 1998) and a common method to measure the ROS generation in live cells is using the 27-dichlorofluorescein dye (DCFH) (Esposti 2002). Justification Objectives and Hypothesis 1. Justification The use

of Mitragyna speciosa Korth or kratom leaves is now popular among traditional users what is kratom leaf used for and drug addicts in Southeast Asia mainly in Malaysia and Thailand.

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